Evidence for oxidative stress in experimental prion disease

Guentchev, M.; Voigtlander, T.; Haberler, C.; Groschup, Martin H. GND; Budka, H.

Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.



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Guentchev, M. / Voigtlander, T. / Haberler, C. / et al: Evidence for oxidative stress in experimental prion disease. 2000.


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