Microbial production of itaconic acid: developing a stable platform for high product concentrations

Kuenz, Anja GND; Gallenmüller, Yvonne; Willke, Thomas GND; Vorlop, Klaus-Dieter GND

Biotechnologically produced itaconic acid (IA) is a promising organic acid with a wide range of applications and the potential to open up new application fields in the area of polymer chemistry, pharmacy, and agriculture. In this study, a systematic process optimization was performed with an own isolated strain of Aspergillus terreus and transferred from a 250-mL to a 15-L scale. An IA concentration of 86.2 g/L was achieved within 7 days with an overall productivity of 0.51 g/(L h), a maximum productivity of 1.2 g/(L h), and a yield of 86 mol%. A cultivation of other well-known A. terreus strains with the developed process showed no significant differences. Based on this, a process is developed providing a high final IA concentration independent of the used strain combined with high reproducibility.

Files

Cite

Citation style:

Kuenz, Anja / Gallenmüller, Yvonne / Willke, Thomas / et al: Microbial production of itaconic acid: developing a stable platform for high product concentrations. 2012.

Rights

Use and reproduction:
All rights reserved

Export