eQTL-Detect: nextflow-based pipeline for eQTL detection in modular format with sharable and parallelizable scripts

Bioinformatic pipelines are becoming increasingly complex with the ever-accumulating amount of Next-generation sequencing (NGS) data. Their orchestration is difficult with a simple Bash script, but bioinformatics workflow managers such as Nextflow provide a framework to overcome respectiv e problems. T his study used Ne xtflo w to de v elop a bioinf ormatic pipeline f or detecting e xpression quantitativ e trait loci (eQTL) using a DSL2 Ne xtflo w modular syntax, to enable sharing the huge demand for computing po w er as well as data access limitation across different partners often associated with eQTL studies. Based on the results from a test run with pilot data by measuring the required runtime and computational resources, the new pipeline should be suitable for eQTL studies in large scale analyses.