Identification of potential thyroid hormone disruptors using the Sandell-Kolthoff reaction as a technology platform.

The Sandell-Kolthoff (SK) reaction, as a “classical” analytical tool for the detection and quantification of minute amounts of iodine, has recently gained interest through its increasing use as a readout for in vitro methods in the thyroid field. As many processes and key functions of the thyroid axis involve the transport or metabolism of iodine-containing molecules, the SK reaction has emerged as a useful and easy-to-use readout for several assays that reflect crucial key functions/molecular initiating events of the hormonal axis, including TH metabolising deiodinases, TH transport via transmembrane transporters (e.g. MCT8) or activity of the sodium/iodide symporter. The webinar will give an overview of the applications and the potential of using a unified SK setup as a central platform to perform in vitro tests and ex vivo analysis.