BeeGUTS – a TKTD model for the interpretation and extrapolation of bee survival data

Affiliation
Wageningen University and Research, ERA, Wageningen, Netherlands
Baas, Jan;
Affiliation
IBACON, Roszdorf, Germany
Goussen, Benoit;
Affiliation
BAYER, BAYER Crop Sciences, Monheim, Germany
Preuss, Thomas G.;
Affiliation
BAYER, BAYER Crop Sciences, Monheim, Germany
Miles, Mark;
Affiliation
BAYER, BAYER Crop Sciences, Monheim, Germany
Roeben, Vanessa;
Affiliation
BAYER, BAYER Crop Sciences, Monheim, Germany
Tänzler, Verena;
Affiliation
Wageningen University and Research, ERA, Wageningen, Netherlands
Roessink, Ivo

There are different tests for testing the impact of chemicals on bees: the acute oral test, the acute contact test and the chronic oral test. For honey bees, OECD guidelines are avialable stating how these tests need to be conducted. The endpoint of the tests is an LD50-value expressed in ug/bee, where the chronic test usually has the most conservative result. In current practise, the results of these tests are interpreted independently and the most conservative result is chosen for further evaluation. Unfortunately, in this approach it is not known how the different exposure regimes influence the result and what the time dependency of the LD50 values is. Extrapolation and interpretation issues between exposure regimes and time can be solved by using a mechanistic approach where time is explicitly considered and effects are interpreted with time-independent parameters. The already developed and published GUTS modelling framework was used as a starting point and was adapted to take into account the physiology of the bees and the details of the different existing tests for bees. It showed that the different bee tests (acute oral, acute contact and chronic) could be interpreted within this framework with one set of parameters describing the toxicity of a compound for bees. The framework was then applied to other be species to compare sensitivity leading to new insights in bee sensitivity and bee testing.

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