Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b: Research Letter

Graaf, Annika; Piesche, Ronja; Sehl-Ewert, Julia; Grund, Christian; Pohlmann, Anne; Beer, Martin; Harder, Timm

doi:10.3201/eid2907.230296

Article Wed Jun 14 2023 CC BY 4.0

refereed

published

Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b : Research Letter

Graaf, Annika ; Piesche, Ronja ; Sehl-Ewert, Julia ; Grund, Christian ; Pohlmann, Anne ; Beer, Martin ; Harder, Timm

We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.