The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features: [Preprint]

Halwe, Nico; Hamberger, Lea; Sehl-Ewert, Julia; Mache, Christin; Schön, Jacob; Ulrich, Lorenz; Calvelage, Sten; Fuchs, Jonas; Bandawane, Pooja; Loganathan, Madhumathi; Abbad, Anass; Carreño, Juan, Manuel; Simon, Viviana; Kayali, Ghazi; Tönnies, Mario; Kandeil, Ahmed; El-Shesheny, Rabeh; Ali, Mohamed; Wolff, Thorsten; Budt, Matthias; Hippenstiel, Stefan; Hocke, Andreas; Krammer, Florian; Schwemmle, Martin; Ciminski, Kevin; Hoffmann, Donata; Bermudez-Gonzalez, Maria; Beer, Martin

doi:10.21203/rs.3.rs-2937503/v1

Preprint Mo., 22. Mai. 2023 CC BY 4.0

Veröffentlicht

The bat-borne influenza A virus H9N2 exhibits a set of unexpected pre-pandemic features : [Preprint]

Halwe, Nico ; Hamberger, Lea; Sehl-Ewert, Julia ; Mache, Christin; Schön, Jacob ; Ulrich, Lorenz ; Calvelage, Sten ; Fuchs, Jonas ; Bandawane, Pooja ; Loganathan, Madhumathi ; Abbad, Anass; Carreño, Juan Manuel; Simon, Viviana ; Kayali, Ghazi ; Tönnies, Mario; Kandeil, Ahmed; El-Shesheny, Rabeh; Ali, Mohamed ; Wolff, Thorsten ; Budt, Matthias; Hippenstiel, Stefan ; Hocke, Andreas ; Krammer, Florian ; Schwemmle, Martin ; Ciminski, Kevin ; Hoffmann, Donata ; Bermudez-Gonzalez, Maria; Beer, Martin

An Old-World bat H9N2 influenza A virus (IAV) identified in Egypt exhibits high replication and transmission potential in ferrets, efficient infection of human lung explant cultures and marked escape from the antiviral activity of MxA. Together with low antigenic similarity to N2 of seasonal human strains, bat H9N2 meets key criteria for pre-pandemic IAVs.

Nachfolger

Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets

Vorschau

Einordnung

Erschienen in:: Research Square : The preprint platform
Auflage:: Version 1
Datum der Veröffentlichung:: 22.05.2023
DOI:: 10.21203/rs.3.rs-2937503/v1
Sprache:: Englisch
Ressourcentyp:: Text
Verlag:: Research Square Platform LLC
DDC-Sachgruppe der DNB:: 570 Biowissenschaften, Biologie
Link URL:: https://www.researchsquare.com/article/rs-2937503/v1
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Virusdiagnostik
Einrichtung:: Friedrich-Loeffler-Institut, Abteilung für experimentelle Tierhaltung und Biosicherheit
Physischer Standort:: SD/2023/189