[Dataset] Raw ILLUMINA NGS data from study on Mouse virulence of European type III and type II x III-recombinant natural clones of Toxoplasma gondii is not always linked to the ROP18 and ROP5 genotype

Veröffentlicht

Whole genome sequences of naturally recombinant European type III and type II x III clones were analyzed
While two of the type II x III recombinants showed an intermediate mouse virulence, a type III clone was highly virulent
Of the three highly virulent clones, only two showed a virulent ROP18-ROP5 allele combination
The mouse virulent type III clone without virulent ROP18-ROP5 allele combination showed the highest level of ROP5 mRNA expression
Two genetically similar clones showed apparent differences in virulence and corresponding IL-12 mRNA expression in infected macrophages

Erschienen in:: Zenodo
Datum der Veröffentlichung:: 21.04.2023
DOI:: 10.5281/zenodo.7852320
Sprache:: Englisch
Ressourcentyp:: Text
Verlag:: Zenodo
Schlagwörter:: Toxoplasma gondii; sexual recombination; mouse virulence; ROP5; ROP16; ROP18; GRA15; Interleukin; IL-12, IL-10; TNFα
DDC-Sachgruppe der DNB:: 570 Biowissenschaften, Biologie
Link URL:: https://zenodo.org/record/7852321
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Epidemiologie
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Virusdiagnostik
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Immunologie