Reverse Genetiksysteme zur Erforschung von Ebola-Viren

Ebolaviruses are among the deadliest viruses known, and work with infectious virus is restricted to laboratories of the highest biosafety level (i. e. BSL4). To facilitate research on ebolaviruses, also for researchers without access to BSL4 laboratories, reverse geneticsbased life cycle modelling systems have been developed. Here, we describe how these system work, provide examples of their applications, and discuss their advantages and limitations.