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  • The Australian dingo is an early offshoot of modern breed dogs
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The Australian dingo is an early offshoot of modern breed dogs

Zugehörigkeit
Centre for Tropical Bioinformatics and Molecular Biology, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4878, Australia; Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia
Field, Matt A.;
Zugehörigkeit
School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia
Yadav, Sonu;
Zugehörigkeit
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA
Dudchenko, Olga;
Zugehörigkeit
School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Esvaran, Meera;
Zugehörigkeit
Animal Genomics and Improvement Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
Rosen, Benjamin D.;
Zugehörigkeit
Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia
Skvortsova, Ksenia;
Zugehörigkeit
School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia
Edwards, Richard J.;
GND
1013858662
Zugehörigkeit
Julius Kühn-Institute (JKI), Institute for Biosafety in Plant Biotechnology, Germany
Keilwagen, Jens;
Zugehörigkeit
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Cochran, Blake J.;
Zugehörigkeit
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Manandhar, Bikash;
Zugehörigkeit
Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2052, Australia
Bustamante, Sonia;
Zugehörigkeit
Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark; Center for Evolutionary Hologenomics, Faculty of Health and Medical Sciences, The GLOBE Institute University of Copenhagen, Copenhagen, Denmark
Rasmussen, Jacob Agerbo;
Zugehörigkeit
Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA
Melvin, Richard G.;
Zugehörigkeit
College of the Environment, Departments of Biology, and Earth and Environmental Sciences, Wesleyan University, Middletown, CT 06459, USA
Chernoff, Barry;
Zugehörigkeit
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA
Omer, Arina;
Zugehörigkeit
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA
Colaric, Zane;
Zugehörigkeit
Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia; Statewide Genomics, New South Wales Health Pathology, 45 Watt St, Newcastle, NSW 2300, Australia
Chan, Eva K. F.;
Zugehörigkeit
Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia
Minoche, Andre E.;
Zugehörigkeit
U.S. Meat Animal Research Center, Agricultural Research Service, USDA, Rd 313, Clay Center, NE 68933, USA
Smith, Timothy P. L.;
Zugehörigkeit
Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark; University Museum, NTNU, Trondheim, Norway
Gilbert, M. Thomas P.;
Zugehörigkeit
Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia
Bogdanovic, Ozren;
Zugehörigkeit
Vineyard Veterinary Hospital, 703 Windsor Rd, Vineyard, NSW 2765, Australia
Zammit, Robert A.;
Zugehörigkeit
School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Thomas, Torsten;
Zugehörigkeit
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA; Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA; UWA School of Agriculture and Environment, The University of Western Australia, Perth, WA 6009, Australia; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Pudong 201210, China; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Aiden, Erez L.;
Zugehörigkeit
Department of Environment and Genetics, SABE, La Trobe University, Melbourne, VIC 3086, Australia; School of Biosciences, University of Melbourne, Royal Parade, Parkville, VIC 3052, Australia
Ballard, J. William O.

Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

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Einordnung

Erschienen in:
Science Advances
Vol. 8, H. 16 Art Nr.:abm5944
Band:
8
Heft:
16
Datum der Veröffentlichung:
2022
Datum der Online-Veröffentlichung:
22.04.2022
DOI:
10.1126/sciadv.abm5944
Scopus ID:
85128884921
Sprache:
Englisch
Ressourcentyp:
Text
Umfang:
14 Seiten
DDC-Sachgruppe der DNB:
630 Landwirtschaft, Veterinärmedizin
Link URL:
https://www.science.org/doi/full/10.1126/sciadv.abm5944
Einrichtung:
Julius Kühn-Institut, Institut für die Sicherheit biotechnologischer Verfahren bei Pflanzen

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