Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

Pfaff, E; Mussgay, M; Böhm, H, O; Schulz, G, E; Schaller, H

doi:10.1002/j.1460-2075.1982.tb01262.x

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Veröffentlicht

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

Pfaff, Eberhard ; Mussgay, Manfred ; Böhm, H. O.; Schulz, G. E.; Schaller, H.

A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha-helix.

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Erschienen in:: The EMBO journal
Vol. 1, H. 7S. 869-874
Band:: 1
Heft:: 7
Datum der Veröffentlichung:: 1982
Sonstiger Identifikator (pubmed):: 6203738
DOI:: 10.1002/j.1460-2075.1982.tb01262.x
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: Animals; Aphthovirus; Antibodies, Viral; Antigen-Antibody Complex; Antigens, Viral; Epitopes; Enzyme-Linked Immunosorbent Assay; Serotyping; Amino Acid Sequence; Genes, Viral
DDC-Sachgruppe der DNB:: 630 Landwirtschaft, Veterinärmedizin
Link URL:: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6203738/pdf/?tool=EBI
Einrichtung:: Friedrich-Loeffler-Institut, Vorgängereinrichtung
Physischer Standort:: SD/1982/3