Artikel CC BY 4.0
referiert
Veröffentlicht

Fusarium culmorum Produces NX-2 Toxin Simultaneously with Deoxynivalenol and 3-Acetyl-Deoxynivalenol or Nivalenol

GND
1235721663
Zugehörigkeit
Julius Kühn-Institute (JKI), Institute of Plant Protection in Field Crops and Grassland, Germany
Schiwek, Simon;
GND
1237647886
Zugehörigkeit
Molecular Phytopathology and Mycotoxin Research, University of Goettingen, D-37077 Goettingen, Germany
Alhussein, Mohammad;
Zugehörigkeit
Plant Phytopathology and Crop Protection, University of Goettingen, D-37077 Goettingen, Germany
Rodemann, Charlotte;
Zugehörigkeit
Department of Bioorganic Chemistry, Leibniz Institute for Plant Biochemistry, D-06120 Halle, Germany
Budragchaa, Tuvshinjargal;
GND
1235725251
Zugehörigkeit
Julius Kühn-Institute (JKI), Institute for Ecological Chemistry, Plant Analysis and Stored Product Protection, Germany
Beule, Lukas;
GND
141364645
Zugehörigkeit
Plant Phytopathology and Crop Protection, University of Goettingen, D-37077 Goettingen, Germany
von Tiedemann, Andreas;
Zugehörigkeit
Molecular Phytopathology and Mycotoxin Research, University of Goettingen, D-37077 Goettingen, Germany
Karlovsky, Petr

Fusarium culmorum is a major pathogen of grain crops. Infected plants accumulate deoxynivalenol (DON), 3-acetyl-deoxynivalenol (3-ADON), or nivalenol (NIV), which are mycotoxins of the trichothecene B group. These toxins are also produced by F. graminearum species complex. New trichothecenes structurally similar to trichothecenes B but lacking the carbonyl group on C-8, designated NX toxins, were recently discovered in atypical isolates of F. graminearum from North America. Only these isolates and a few strains of a yet to be characterized Fusarium species from South Africa are known to produce NX-2 and other NX toxins. Here, we report that among 20 F. culmorum strains isolated from maize, wheat, and oat in Europe and Asia over a period of 70 years, 18 strains produced NX-2 simultaneously with 3-ADON and DON or NIV. Rice cultures of strains producing 3-ADON accumulated NX-2 in amounts corresponding to 2–8% of 3-ADON (1.2–36 mg/kg). A strain producing NIV accumulated NX-2 and NIV at comparable amounts (13.6 and 10.3 mg/kg, respectively). In F. graminearum, producers of NX-2 possess a special variant of cytochrome P450 monooxygenase encoded by TRI1 that is unable to oxidize C-8. In F. culmorum, producers and nonproducers of NX-2 possess identical TRI1; the reason for the production of NX-2 is unknown. Our results indicate that the production of NX-2 simultaneously with trichothecenes B is a common feature of F. culmorum.

Vorschau

Zitieren

Zitierform:
Zitierform konnte nicht geladen werden.

Zugriffsstatistik

Gesamt:
Volltextzugriffe:
Metadatenansicht:
12 Monate:
Volltextzugriffe:
Metadatenansicht:

Rechte

Rechteinhaber: 2022 by the authors.

Nutzung und Vervielfältigung: