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Tolerance and persistence of ebola virus in primary cells from mops condylurus, a potential ebola virus reservoir

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1228595372
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Bokelmann, Marcel;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Vogel, Uwe;
Affiliation
Department of Infectious Diseases, King’s College London, London, United Kingdom
Debeljak, Franka;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Düx, Ariane;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Riesle‐sbarbaro, Silke;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Lander, Angelika;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Wahlbrink, Annette;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Kromarek, Nicole;
Affiliation
Department of Infectious Diseases, King’s College London, London, United Kingdom
Neil, Stuart;
Affiliation
Laboratoire National d’Appui au Développement Agricole, BP 206, Bingerville, Cote d'Ivoire
Couacy‐hymann, Emmanuel;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Prescott, Joseph;
Affiliation
Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany
Kurth, Andreas

Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free‐tailed bat (Mops condylurus), an insectivorous microbat, is a possible ebolavirus reser-voir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from M. condylurus. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells, without resultant selective pressure leading to virus mutation, indicate the intrinsic ability of EBOV to persist in this bat species. These results provide further evidence for this bat species to be a likely reservoir of ebolaviruses.

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