Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract

Wylezich, Claudia; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk; Schlegel, Jürgen; Beer, Martin; Dintner, Sebastian

doi:10.1016/j.diagmicrobio.2021.115520

Artikel Fr., 20. Aug.. 2021 CC BY 4.0

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Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients’ upper and lower respiratory tract

Wylezich, Claudia ; Schaller, Tina; Claus, Rainer; Hirschbühl, Klaus; Märkl, Bruno; Kling, Elisabeth; Spring, Oliver; Höper, Dirk ; Schlegel, Jürgen; Beer, Martin ; Dintner, Sebastian

Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed.

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Erschienen in:: Diagnostic microbiology and infectious disease
Vol. 101, H. 4 Art Nr.:115520
Band:: 101
Heft:: 4
Datum der Veröffentlichung:: 20.08.2021
Datum der Print-Veröffentlichung:: 01.12.2021
Datum der Online-Veröffentlichung:: 20.08.2021
DOI:: 10.1016/j.diagmicrobio.2021.115520
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: Postmortem; Intra-Host Virus Evolution; Orf8 5-Nucleotide Deletion; S-614d; Sars-Cov-2 Genome Sequences; Upper And Lower Respiratory Tract
DDC-Sachgruppe der DNB:: 570 Biowissenschaften, Biologie
Link URL:: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376524/?tool=EBI
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Virusdiagnostik
Physischer Standort:: SD/2021/420