Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2)

Pfaff, Florian GND; Neubauer-Juric, Antonie; Krebs, Stefan; Hauser, Andreas; Singer, Stefanie; Blum, Helmut; Hoffmann, Bernd GND

We present the complete genome sequence of bovine alphaherpesvirus 2 (BoHV-2), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus. BoHV-2 is the causative agent of bovine ulcerative mammillitis (bovine herpes mammillitis) and pseudo-lumpy skin disease. The genomic architecture of BoHV-2 is typical of most simplexvirus genomes and congruent with that of human alphaherpesvirus 1 (HHV-1). The genome comprises a total of 131,245 base pairs and has an overall G+C content of 64.9 mol%. A total of 75 open reading frames are predicted. The gene repertoire of BoHV-2 is analogous to that of HHV-1, although the coding region of US12 is missing. A phylogenetic analysis supported BoHV-2 as a member of the genus Simplexvirus.

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Pfaff, Florian / Neubauer-Juric, Antonie / Krebs, Stefan / et al: Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2). 2020.

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