Sequence Analysis of Egyptian Foot-And-Mouth Disease Virus Field and Vaccine Strains: Intertypic Recombination and Evidence for Accidental Release of Virulent Virus : [Preprint]

Abd El Rahman, Sahar; Hoffmann, Bernd GND; Karam, Reham; El-Beskawy, Mohamed; Hamed, Mohammed F.; Forth, Leonie GND; Höper, Dirk GND; Eschbaumer, Michael GND

In addition to the risk of vaccine failure caused by strain mismatch, the production of inactivated FMD vaccines is dangerous if adequate biosafety cannot be maintained. Using a high-throughput sequencing protocol optimized for short nucleic acid fragments, the composition of a local inactivated vaccine was analyzed in depth. The serotype O strain identified in the vaccine was genetically identical to viruses found in recent FMD outbreaks in Egypt.

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Abd El Rahman, Sahar / Hoffmann, Bernd / Karam, Reham / et al: Sequence Analysis of Egyptian Foot-And-Mouth Disease Virus Field and Vaccine Strains: Intertypic Recombination and Evidence for Accidental Release of Virulent Virus. [Preprint]. 2020.

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