HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis

Corleis, Björn; Bucsan, Allison N.; Deruaz, Maud; Vrbanac, Vladimir D.; Lisanti-Park, Antonella C.; Gates, Samantha J.; Linder, Alice H.; Paer, Jeffrey M.; Olson, Gregory S.; Bowman, Brittany A.; Schiff, Abigail E.; Medoff, Benjamin D.; Tager, Andrew M.; Luster, Andrew D.; Khader, Shabaana A.; Kaushal, Deepak; Kwon, Douglas S.

Lung interstitial CD4+ T cells are critical for protection against pulmonary infections, but the fate of this population during HIV-1 infection is not well described. We studied CD4+ T cells in the setting of HIV-1 infection in human lung tissue, humanized mice, and a Mycobacterium tuberculosis (Mtb)/simian immunodeficiency virus (SIV) nonhuman primate co-infection model. Infection with a CCR5-tropic strain of HIV-1 or SIV results in severe and rapid loss of lung interstitial CD4+ T cells but not blood or lung alveolar CD4+ T cells. This is accompanied by high HIV-1 production in these cells in vitro and in vivo. Importantly, during early SIV infection, loss of lung interstitial CD4+ T cells is associated with increased dissemination of pulmonary Mtb infection. We show that lung interstitial CD4+ T cells serve as an efficient target for HIV-1 and SIV infection that leads to their early depletion and an increased risk of disseminated tuberculosis.

Cite

Citation style:

Corleis, Björn / Bucsan, Allison / Deruaz, Maud / et al: HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis. 2019.

Rights

Use and reproduction:

Export