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DHA-induced perturbation of human serum metabolome. Role of the food matrix and Co-administration of oat β-glucan and anthocyanins

Affiliation
Center of Magnetic Resonance (CERM), University of Florence, via Luigi Sacconi, Sesto Fiorentino, Italy
Ghini, Veronica;
Affiliation
Center of Magnetic Resonance (CERM), University of Florence, via Luigi Sacconi, Sesto Fiorentino, Italy
Tenori, Leonardo;
Affiliation
Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, Piazza G. Goidanich, 60, Cesena, Italy
Capozzi, Francesco;
Affiliation
Center of Magnetic Resonance (CERM), University of Florence, via Luigi Sacconi, Sesto Fiorentino, Italy
Luchinat, Claudio;
GND
1043667814
Affiliation
Max Rubner-Institut (MRI), Federal Research Institute of Nutrition and Food, Department of Physiology and Biochemistry of Nutrition, Germany
Bub, Achim;
Affiliation
Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France
Malpuech-Brugere, Corinne;
Affiliation
School of Food Science and Nutrition, University of Leeds, Woodhouse Ln, Leeds, United Kingdom
Orfila, Caroline;
Affiliation
Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, Piazza G. Goidanich, 60, Cesena, Italy
Ricciardiello, Luigi;
Affiliation
Department of Agricultural and Food Sciences, Alma Mater Studiorum University of Bologna, Piazza G. Goidanich, 60, Cesena, Italy
Bordoni, Alessandra

Docosahexaenoic acid (DHA) has been reported to have a positive impact on many diet-related disease risks, including metabolic syndrome. Although many DHA-enriched foods have been marketed, the impact of different food matrices on the effect of DHA is unknown. As well, the possibility to enhance DHA effectiveness through the co-administration of other bioactives has seldom been considered. We evaluated DHA effects on the serum metabolome administered to volunteers at risk of metabolic syndrome as an ingredient of three different foods. Foods were enriched with DHA alone or in combination with oat beta-glucan or anthocyanins and were administered to volunteers for 4 weeks. Serum samples collected at the beginning and end of the trial were analysed by NMR-based metabolomics. Multivariate and univariate statistical analyses were used to characterize modifications in the serum metabolome and to evaluate bioactive-bioactive and bioactive-food matrix interactions. DHA administration induces metabolome perturbation that is influenced by the food matrix and the co-presence of other bioactives. In particular, when co-administered with oat beta-glucan, DHA induces a strong rearrangement in the lipoprotein profile of the subjects. The observed modifications are consistent with clinical results and indicate that metabolomics represents a possible strategy to choose the most appropriate food matrices for bioactive enrichment.

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