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RNA-based biocontrol compounds: current status and perspectives to reach the market

Affiliation
Laboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
Taning, Clauvis NT;
Affiliation
Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), DTE-BBC, Rotondella, Italy
Arpaia, Salvatore;
Affiliation
Laboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
Christiaens, Olivier;
GND
1058992457
Affiliation
Julius Kühn-Institut (JKI), Federal Research Centre for Cultivated Plants, Institute for Biosafety in Plant Biotechnology, Braunschweig, Germany
Dietz-Pfeilstetter, Antje;
Affiliation
IBERS, Aberystwyth University, Aberystwyth, United Kingdom
Jones, Huw;
Affiliation
Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche (UPM), Ancona, Italy
Mezzetti, Bruno;
Affiliation
Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche (UPM), Ancona, Italy
Sabbadini, Silvia;
Affiliation
Norwegian University of Life Sciences, Norway
Sorteberg, Hilde-Gunn;
Affiliation
JT Environmental Consultants Ltd, Cambridge, United Kingdom
Sweet, Jeremy;
Affiliation
Department of Environmental Science and Policy, Università degli Studi di Milano, Milan, Italy
Ventura, Vera;
Affiliation
Laboratory of Agrozoology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
Smagghe, Guy

Facing current climate challenges and drastically reduced chemical options for plant protection, the exploitation of RNA interference (RNAi) as an agricultural biotechnology tool has unveiled possible new solutions to the global problems of agricultural losses caused by pests and other biotic and abiotic stresses. While the use of RNAi as a tool in agriculture is still limited to a few transgenic crops, and only adopted in restricted parts of the world, scientists and industry are already seeking innovations in leveraging and exploiting the potential of RNAi in the form of RNA-based biocontrol compounds for external applications. Here, we highlight the expanding research and development pipeline, commercial landscape and regulatory environment surrounding the pursuit of RNA-based biocontrol compounds with improved environmental profiles. The commitments of well-established agrochemical companies to invest in research endeavours and the role of start-up companies are crucial for the successful development of practical applications for these compounds. Additionally, the availability of standardized guidelines to tackle regulatory ambiguities surrounding RNA-based biocontrol compounds will help to facilitate the entire commercialization process. Finally, communication to create awareness and public acceptance will be key to the deployment of these compounds. © 2019 Society of Chemical Industry.

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License Holder: 2019 Society of Chemical Industry

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