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The blaNDM₋₁-Carrying IncA/C₂ Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo

Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Hadziabdic, Sead;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Fischer, Jennie;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Borowiak, Maria;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Malorny, Burkhard;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Juraschek, Katharina;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Kaesbohrer, Annemarie;
Zugehörigkeit
European Food Safety Authority, Parma, Italy
Guerra, Beatriz;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Deneke, Carlus;
Zugehörigkeit
Departamento de Sanidad Animal and Centro de Vigilancia Sanitaria Veterinaria, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
Gonzalez-Zorn, Bruno;
Zugehörigkeit
Department for Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Szabo, Istvan

In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a blaNDM-1 multiresistance IncA/C2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this blaNDM-1-carrying IncA/C2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into the type and frequency of its structural alterations after an in vivo passage in a broiler chicken infection study.

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