Article CC BY-NC 4.0
refereed
published

Global patterns of avian influenza A(H7): virus evolution and zoonotic threats

Affiliation
Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden.
Naguib, Mahmoud M.;
Affiliation
Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, SE-391 82 Kalmar, Sweden.
Verhagen, Josanne H.;
Affiliation
Institute of Medical Virology, Justus Liebig University Giessen, Giessen 35392, Germany.
Mostafa, Ahmed;
Affiliation
WHO Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Victoria, Australia.
Wille, Michelle;
Affiliation
MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London W2 1PG, United Kingdom.
Li, Ruiyun;
GND
1185989099
Affiliation
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems 17493, Germany.
Graaf, Annika;
Affiliation
Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden.
Järhult, Josef D.;
Affiliation
Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden.
Ellström, Patrik;
Affiliation
Department of Microbiology, National Veterinary Institute, Uppsala SE-75189, Sweden.
Zohari, Siamak;
Affiliation
Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala SE-75237, Sweden.
Lundkvist, Åke;
Affiliation
Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala SE-75185, Sweden.
Olsen, Björn

Avian influenza viruses (AIVs) continue to impose a negative impact on animal and human health worldwide. In particular, the emergence of highly pathogenic AIV H5 and, more recently, the emergence of low pathogenic AIV H7N9 has led to enormous socio-economical losses in the poultry industry and resulted in fatal human infections. While H5N1 remains infamous, the number of zoonotic infections with H7N9 has far surpassed those attributed to H5. Despite the clear public health concerns posed by AIV H7, it is unclear why specifically this virus became endemic in poultry and emerged in humans. In this review, we bring together data on global patterns of H7 circulation, evolution, and emergence in humans. Specifically, we discuss data from the wild bird reservoir, expansion and epidemiology in poultry, the significant increase of their zoonotic potential since 2013, and genesis of highly pathogenic H7. In addition, we analysed available sequence data from an evolutionary perspective, demonstrating patterns of introductions into distinct geographic regions and reassortment dynamics. The integration of all aspects is crucial in the optimisation of surveillance efforts in wild birds, poultry and humans, and we emphasize the need for a One Health approach in controlling emerging viruses such as H7 AIV.

Cite

Citation style:
Could not load citation form.

Access Statistic

Total:
Downloads:
Abtractviews:
Last 12 Month:
Downloads:
Abtractviews:

Rights

Use and reproduction:

Export