Freisetzung von Herpesviruskapsiden aus dem Kern

Klupp, Barbara GND; Rönfeldt, Sebastian GND; Mettenleiter, Thomas C. GND

Herpesvirus nucleocapsids are formed in the nucleus but mature into virions in the cytoplasm. Canonical nucleo-cytoplasmic transport is restricted to the nuclear pore which is too small for passage of the ca. 120 nm nucleocapsid. Therefore, herpesviruses use a special, vesicle-mediated transfer by budding of nucleocapsids at the inner nuclear membrane involving a heterodimeric viral protein complex followed by fusion with the outer nuclear membrane. A similar cellular mechanism might exist allowing other large cargo to leave the nucleus.

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Klupp, Barbara / Rönfeldt, Sebastian / Mettenleiter, Thomas: Freisetzung von Herpesviruskapsiden aus dem Kern. 2019.

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