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Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland

Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Nuñez-Garcia, Javier;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Downs, Sara H.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Parry, Jessica E.;
Affiliation
Veterinary Service, Department of Agriculture and Rural Development, Belfast, United Kingdom
Abernethy, Darrell A.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Broughan, Jennifer M.;
Affiliation
AusVet Animal Health Services Pty Ltd., PO Box 3180, South Brisbane, Australia
Cameron, Angus R.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Cook, Alasdair J.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
de la Rua-Domenech, Ricardo;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Goodchild, Anthony V.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Gunn, Jane;
Affiliation
Centre for Veterinary Epidemiology and Risk Analysis, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
More, Simon J.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Rhodes, Shelley;
Affiliation
Office of the Chief Veterinary Officer, Welsh Government, Cardiff, United Kingdom
Rolfe, Simon;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Sharp, Michael;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Upton, Paul A.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Vordermeier, H. Martin;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Watson, Eamon;
Affiliation
Veterinary Sciences Division, Agri-Food & Biosciences Institute (AFBI), Belfast, United Kingdom
Welsh, Michael;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Whelan, Adam O.;
Affiliation
The Roslin Institute, Roslin Biocentre, Roslin, Midlothian, United Kingdom
Woolliams, John A.;
Affiliation
Animal and Plant Health Agency (APHA), Weybridge, Surrey, United Kingdom
Clifton-Hadley, Richard S.;
Affiliation
Federal Institute for Risk assessment (BfR), Veterinary University Hannover, Foundation, Berlin, Germany
Greiner, Matthias

Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accurate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was, through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 different ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic review of the scientific literature (published 1934–2009) diagnostic Se and Sp were estimated using Bayesian logistic regression models adjusting for confounding factors. Random effect terms were used to account for unexplained heterogeneity. Parameters in the models were implemented using Markov Chain Monte Carlo (MCMC), and posterior distributions for the diagnostic parameters with adjustment for covariates (confounding factors) were obtained using the inverse logit function. Estimates for Se and/or Sp of the tuberculin skin tests and the IFN-γ blood test were compared with estimates published 2010–2015. Median Se for the single intradermal comparative cervical tuberculin skin (SICCT) test (standard interpretation) was 0.50 and Bayesian credible intervals (CrI) were wide (95% CrI 0.26, 0.78). Median Sp for the SICCT test was 1.00 (95% CrI 0.99, 1.00). Estimates for the IFN-γ blood test Bovine Purified Protein Derivative (PPD)-Avian PPD and Early Secreted Antigen target 6 and Culture Filtrate Protein 10 (ESAT-6/CFP10) ESAT6/CFP10 were 0.67 (95% CrI 0.49, 0.82) and 0.78 (95% CrI 0.60, 0.90) respectively for Se, and 0.98 (95% CrI 0.96, 0.99) and 0.99 (95% CrI 0.99, 1.00) for Sp. The study provides an overview of the accuracy of a range of contemporary diagnostic tests for bTB in cattle. Better understanding of diagnostic test performance is essential for the design of effective control strategies and their evaluation.

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