Scientific Opinion on the safety and efficacy of pantothenic acid (calcium D-pantothenateand D-panthenol) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG

The use of calcium D-pantothenate in feed and water for drinking and of D-panthenol in water for drinking is safe for all animal species and categories. The use of calcium D-pantothenate and D-panthenol as nutritional additives does not give rise to concern for consumers. Data from an acute inhalation toxicity study allowed to consider the substance of low toxicity by inhalation. D-panthenol being currently only available in liquid preparations, the FEEDAP Panel does not anticipate any inhalation hazard. Calcium D-pantothenate is not regarded as an irritant to skin and eyes; because of the lack of data it is considered as a skin sensitiser. D-Panthenol is regarded as a skin and eye irritant; D-panthenol was not a skin sensitiser in guinea pigs, however allergic rashes in humans have been reported following its topical use. A risk for the environment resulting from the use of pantothenic acid in animal nutrition is not foreseen. Due to its established nutritional role in domestic animals, calcium D-pantothenate is regarded as an effective source of pantothenic acid. D-Panthenol is considered a pro-vitamin essentially bioequivalent to pantothenic acid.