Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli (FERM BP-11383) for all animal species, based on a dossier submitted by Ajinomoto Eurolysine S.A.S.

The product L-threonine, intended for use as a feed additive, is produced by fermentation with a genetically modified strain of Escherichia coli (FERM BP 11383). Neither the production strain nor its recombinant DNA were detected in the product. The product does not raise safety concerns with regard to the genetic modification. L-Threonine, technically pure, produced by E. coli (FERM BP-11383) is considered safe for the target species when used to meet the animals’ nutritional requirements. As the composition of tissues and products of animal origin will not be changed by the use of the product in animal nutrition, and considering its high purity, no risks are expected for the consumer from the use of the product as a feed additive. The product is considered not irritating to the skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is no evidence of acute toxicity by the inhalation route. The use of the product as a feed additive does not represent a risk to the environment. The product is considered as an efficacious source of the amino acid L-threonine for all animal species. Supplemental L-threonine is degraded by ruminal microorganisms if not given in a protected form.