Scientific Opinion on the safety and efficacy of L-threonine (ThreAMINO®) produced by Escherichia coli (DSM 25086) for all animal species and categories based on a dossier submitted by Evonik Industries A.G.

The product L-threonine, technically pure, is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli. Neither the production strain nor its recombinant DNA was detected in the final product. Therefore, the final product does not raise concerns with regard to the genetic modification of the production strain. The additive L-threonine is safe for all target animal species when supplemented in appropriate amounts to diets. However, the FEEDAP Panel has concerns about the safety of L-threonine for target species when administered via water for drinking because any additional supply of an essential amino acid would disturb the amino acid balance. Since the composition of tissues and products of animal origin will not be changed by the use of L-threonine in animal nutrition, and considering the high purity of the product under assessment, no risks are expected for the consumer from the use of L-threonine, technically pure, as a feed additive. There is no evidence of specific concerns for user safety (inhalation toxicity, skin and eyes irritation and dermal sensitisation) regarding the L-threonine products tested. The use of L-threonine as a feed additive does not give rise to any environmental safety concern. The product L-threonine, technically pure, is regarded as an efficacious source of supplemented amino acid for all animal species. A response in ruminants requires some degree of protection of L-threonine from ruminal degradation.