Neosporosis in Animals

Chapter 1: History of Neospora and Neosporosis -- 1.1 History -- 1.1.1 Discovery of the Organism in Dogs -- 1.1.2 In Vitro Cultivation of Viable N. caninum -- 1.1.3 Linking N. caninum to Abortions in Cattle -- 1.1.4 Retrospective Studies -- 1.1.4.1 Dogs in USA -- 1.1.4.2 Dogs in Norway -- 1.1.5 Cattle and Other Hosts -- 1.2 Landmarks in the Biology of Neospora -- Bibliography -- Chapter 2: General Biology -- 2.1 Introduction -- 2.2 Taxonomic Classification -- 2.3 Hosts -- 2.3.1 Definitive Hosts -- 2.3.2 Intermediate Hosts -- 2.4 Life Cycle Stages -- 2.4.1 Tachyzoite -- 2.4.2 Bradyzoites and Tissue Cysts -- 2.4.2.1 Conversion of Tachyzoites to Bradyzoites -- 2.4.3 Oocyst -- 2.5 Transmission and Epidemiology -- 2.6 Host-Parasite Relationship -- 2.7 Molecular and Cell Biology -- 2.7.1 Genome and Transcriptome Analysis of N. caninum -- 2.7.2 Modulation of Host Gene Expression upon Infection -- 2.7.3 Proteomics Approaches -- 2.7.4 Genetic Manipulation of N. caninum -- 2.7.5 Neospora-Host Cell Interactions and Invasion -- 2.7.5.1 Initial Host Cell Contact is Mediated by Parasite Surface Antigens (SAGs) -- 2.7.5.2 Secretory Organelle Discharge Governs Host Cell Invasion -- 2.7.5.3 Microneme Proteins -- 2.7.5.4 ROPs and Rhoptry Neck Proteins (RONs) -- 2.7.5.5 Dense Granule Proteins -- 2.7.5.6 Intracellular Host Cell Modulation and Parasite-Host Cell Crosstalk -- 2.7.5.7 Monoclonal Antibodies -- 2.8 Rodent Models of Neosporosis -- 2.8.1 Mice -- 2.8.1.1 Outbred Mice -- 2.8.1.2 Inbred Mice -- 2.8.1.3 Nude Mice and IFN-γ-KO Mice -- 2.8.2 Gerbils -- 2.8.2.1 Common Pet Gerbil (Meriones unguiculatus) -- 2.8.2.2 Tristram's Jird (Meriones tristrami) -- 2.8.2.3 Wagner Gerbil (Gerbillus dasyurus)