Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 12 compounds belonging to chemical group 29 (thiazoles, thiophene and thiazoline). They are currently authorised as flavours in food. This opinion concerns 10 compounds from this group. The FEEDAP Panel concludes that 2-isopropyl-4-methylthiazole is safe at the proposed maximum use level of 0.5 mg/kg complete feed for cattle, salmonids and non-food producing animals and at the proposed normal use level of 0.1 mg/kg complete feed for pigs and poultry. All the other compounds, 4, 5-dihydrothiophen-3(2H)-one, 2-isobutylthiazole, 5-(2-hydroxyethyl)-4-methylthiazole, benzothiazole, 2,4, 5-trimethylthiazole, 2-acetylthiazole, 2-ethyl-4-methylthiazole, 5,6-dihydro-2,4,6-trans(2-methylpropyl) 4H-1,3,5-dithiazine and thiamine hydrochloride are safe at the proposed maximum use level of 0.05 mg/kg feed for all animal species. No safety concern would arise for the consumer from the use of these compounds up to the highest safe level in feeds. Hazards for skin and eye contact and respiratory exposure are recognised for the majority of the compounds under application. Most are classified as irritating to the respiratory system. The concentrations considered safe for the target species are unlikely to have detrimental effects on the terrestrial and fresh water environments. As all the compounds under assessment are used in food as flavourings, and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary. In the absence of data on the stability in water for drinking, the FEEDAP Panel is unable to conclude on the safety or efficacy of the substances under this mode of delivery.