Untersuchungen über den Verlauf einer Infektion mit Border-Disease-Virus in einer Schafherde und ein Vorschlag zur Bekämpfung der Krankheit

Straub, Otto GND; Merkle, A. B.; Weiland, Emilie GND

A female lamb persistently infected with Border disease virus was placed in contact with a sero-negative ewe and its female offspring. A sero-negative ram was introduced later. The experiment was concluded after five years, when the flock comprised 22 animals. A total of 36 animals, including a still-born lamb, had been examined by this time. Only the four lambs born to the persistently infected ewe became persistently infected Two of these four animals were raised with difficulty. All of the other sheep developed specific virus neutralizing antibodies to the noncytopathogenic virus shed by the persistently infected animals. The only clinical signs were hairy coat and ill thrift. Body temperatures and while blood cell pictures were essentially the same in infected and immune sheep. Virus neutralizing antibodies were absent in the persistently infected sheep with the exception of one animal. An immunoperoxidase assay demonstrated cross-reactivity with one of twenty-one monoclonal anti-BVDV antibodies and with one anti-HCV antibody to the envelope glycoprotein BVDV-gp53 and HCV-gp55. The control of the disease is relatively straightforward. Offspring of persistently infected ewes can be recognised from their hairy coat. These have to be removed together with their dams. Introductions to a flock should only be made during the >>open<< months. It is advisable to test such animals during the quarantine period for the presence of antibodies and virus. In questionable cases the whole flock should be vaccinated with a BVD vaccine

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Straub, Otto / Merkle, A. / Weiland, Emilie: Untersuchungen über den Verlauf einer Infektion mit Border-Disease-Virus in einer Schafherde und ein Vorschlag zur Bekämpfung der Krankheit. 1993.

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