Zur Diagnostik der Bovinen Spongiformen Enzephalopathie und der Traberkrankheit (Scrapie) der kleinen Wiederkäuer: 1. Mitteilung: Möglichkeiten und Grenzen der Diagnostik

Groschup, Martin H. GND; Weiland, Frank GND; Straub, Otto GND

Scrapie is a transmissible spongiform encephalopathy in sheep and goats and has been known for centuries worldwide. Transmission of the scrapie agent to cattle initiated a fulminating epidemic of bovine spongiform encephalopathy (BSE) in the United Kingdom. This article reviews the capabilities and limits of current diagnostic techniques: histopathological detection of degenerative processes, electronmicroscopical detection of proteinase K-resistant fibrils and the imunoblot detection of proteinase K-resistant so-called prion protein in the central nervous system of diseased animals. The mouse inoculation test, the increase of enolase activity in cerebrospinal fluid, the electro-encephalographic detection of typical spike patterns and the increase in the electro-chemical redox-potential in urine of animals suffering from BSE and scrapie are currently not suitable for use in routine diagnosis

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Groschup, Martin / Weiland, Frank / Straub, Otto: Zur Diagnostik der Bovinen Spongiformen Enzephalopathie und der Traberkrankheit (Scrapie) der kleinen Wiederkäuer: 1. Mitteilung: Möglichkeiten und Grenzen der Diagnostik. 1994.

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