One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle

Garrels, Wiebke GND; Talluri, Thirumala Rao GND; Apfelbaum, Ronja GND; Carratalá, Y.P.; Bosch, P.; Pötzsch, K.; Grueso, E.; Ivics, Z.; Kues, Wilfried August GND

Genetically modified cattle are important for developing new biomedical models and for an improved understanding of the pathophysiology of zoonotic diseases. However, genome editing and genetic engineering based on somatic cell nuclear transfer suffer from a low overall efficiency. Here, we established a highly efficient one-step multiplex gene transfer system into the bovine genome.

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Garrels, Wiebke / Talluri, Thirumala Rao / Apfelbaum, Ronja / et al: One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle. 2016.

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