Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells

Groll, N.; Kollotzek, F.; Goepfert, J.; Joos, T. O.; Schwarz, M.; Braeuning, A.

The antiepileptic drug phenobarbital (PB) exerts hepatic effects related to cell proliferation and tumorigenesis which are closely linked to the Wnt/beta-catenin signaling pathway. This pathway is, amongst others, regulated by calpain proteases. We now identified PB as an inhibitor of Wnt/beta-catenin signaling in mouse hepatoma cells. Further analyses revealed that PB inhibits calpain activity, an effect which is at least in parts mediated by a transcriptional regulation of calpain mRNA levels and which is furthermore independent of the constitutive androstane receptor, the known mediator of most effects of PB in liver cells.

Zitieren

Zitierform:

Groll, N. / Kollotzek, F. / Goepfert, J. / et al: Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells. 2016.

Rechte

Nutzung und Vervielfältigung:
Alle Rechte vorbehalten

Export