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Vakzination von Absatzferkeln gegen Klassische Schweinepest mit der Subunit-Vakzine "Porcilis Pest" : Einfluss des Vakzinationsschemas auf Challengevirusausscheidung und -übertragung

Excretion and transmission of CSFV after vaccination with the CSF subunit marker vaccine "Porcilis(R) Pesti" have been studied using the following different vaccination schedules: Group A - two vaccinations with an interval of 28 d, challenge 14 d after second vaccination (p.v(2).); group B - two vaccinations with an interval of 14 d, challenge 14 d later; group C - two vaccinations with an interval of 28 d, challenge at time of booster vaccination; group D - two vaccinations with an interval of 14 d, challenge 7 d p.v(2).; group E single vaccination and infection 14 d later. After infection one sentinel pig was added to the vaccinated and infected pigs of each group. A single vaccination did not induce protective immunity against a CSFV challenge. Double vaccination at a four-week interval protected piglets from clinical infection, and neither viraemia and leukopenia nor virus excretion were detected if infected 14 d p.v(2). Two vaccinations at a two-week interval followed by a challenge 7 d p.v(2). led to a short viraemia on day 5 p.i. but without excretion of CSFV. Though all other vaccination schedules induced a reduction in virus shedding and a decrease in CSFV replication, in all these cases in-contact controls became infected. The results of transmission of CSFV are discussed in relation to a potential use of subunit marker vaccines in CSF control

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