The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss)

Dijkstra, J.M.; Yoshiura, Y.; Kiryu, I.; Aoyagi, K.; Köllner, Bernd GND; Fischer, Uwe GND; Nakanishi, T.; Ototake, M.

In rainbow trout only a single classical major histocompatibility complex (MHC) class I locus has been identified. In previous studies it was shown that this locus, Onmy-UBA, is characterised by extensive polymorphism and ubiquitous expression. In the present study the sequence of the promoter region of Onmy-UBA was analysed. Within this region several fragments for transcription regulation could be detected, including interferon-sensitive enhancer elements. The promoter region is very similar to that of classical MHC class I in higher vertebrates. In agreement with the interferon sensitive elements identified in its promoter, Onmy-UBA expression in rainbow trout gonad cells (RTG-2 cell line) was up-regulated after infection with infectious haematopoietic necrosis virus (IHNV).

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Dijkstra, J.M. / Yoshiura, Y. / Kiryu, I. / et al: The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss). 2003.

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