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Vitamin K requirement and reproduction in bromadiolone-resistant Norway rats

GND
122411307
Affiliation
Julius Kühn-Institute (JKI), Institute for Plant Protection in Horticulture and Forests, Germany
Jacob, Jens;
Affiliation
Bayer CropScience AG, Environmental Science – Innovations,Monheim, Germany
Endepols, Stefan;
GND
1059386364
Affiliation
Julius Kühn-Institute (JKI), Institute for Plant Protection in Horticulture and Forests, Germany
Pelz, Hans-Joachim;
Affiliation
Julius Kühn-Institute (JKI), Institute for Plant Protection in Horticulture and Forests, Germany
Kampling, Engelbert;
Affiliation
University Münster, Centre for Reproductive Andrology, Münster, Germany
Cooper, Trevor G.;
Affiliation
University Münster, Centre for Reproductive Andrology, Münster, Germany
Yeung, Ching Hei;
Affiliation
University Münster, Centre for Reproductive Andrology, Münster, Germany
Redmann, Klaus;
Affiliation
University Münster, Centre for Reproductive Andrology, Münster, Germany
Schlatt, Stefan

BACKGROUND: Nucleotide polymorphisms in the VKORC1 gene can be linked to anticoagulant rodenticide resistance in Norway rats (Rattus norvegicus Berkenhout). This provides a fitness advantage to rats exposed to anticoagulant actives, but may also cause fitness costs. The vitamin K requirement and reproductive parameters of bromadiolone-resistant rats (Westphalian resistant strain; VKOR variant Tyr139Cys) and bromadiolone-susceptible Norway rats were compared. RESULTS: At vitamin K deficiency, blood clotting times increased in all homozygous resistant males within 8 days and in 80% of homozygous resistant females within 15 days. There was little effect on blood clotting in heterozygous males and no effect in heterozygous females and VKOR wild-type individuals. Litter size was about 20% higher in sensitive pairs compared with resistant pairs. Testes growth, male gonad weight, sperm motility and testis cell concentration were unaffected by the mutation. CONCLUSIONS: The VKOR variant Tyr139Cys causes considerable physiological cost in Norway rats in terms of vitamin K requirement and reproduction. This may affect the distribution and spread of resistant individuals in the wild. Decreased litter size of resistant parents seems to be due to lowered female reproductive performance, as there was no significant effect of the mutation on any aspects of male reproduction considered, but this requires further study

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