Highly ciprofloxacin resistant Salmonella enterica serovar Kentucky isolates of human and animal origin in Germany

Beutlich, J.; Guerra, B.; Schroeter, A.; Tietze, E.; Szabo, I.; Helmuth, R.

National Salmonella surveillance in France, England, Wales, Denmark and the USA recorded in recent years about 500 human infections caused by multidrug-resistant Salmonella enterica Serovar ( S .) Kentucky isolates displaying high-level resistance to fluoroquinolones (ciprofloxacin, MIC > or = 4 mg/l), which were referred to clone ST198-X1. To determine whether this clone is also present in German S. Kentucky isolates, the National Reference Laboratory for Salmonella (NRL-Salm) at the Federal Institute for Risk Assessment (BfR) analyzed the trend of S . Kentucky isolates received over the past years. Since 2010 the first submissions of highly ciprofloxacin resistant S. Kentucky isolates, especially from turkey meat products, were recorded. Thirty-two isolates originating from animal, food and non-human sources, and in addition 30 human isolates from the National Reference Centre of Salmonella and other enterics at the Robert Koch Institute (RKI) with MIC values of > or = 8 mg/l to ciprofloxacin were analysed. Molecular biological typing methods showed most of the German S. Kentucky isolates were identical to the clone described by Le Hello et al. (2011) and carried a multidrug resistance encoding region (SGI1). Since WHO considers fluoroquinolones to be drugs of critical importance in human and veterinary medicine, the spread of ST198-X1 S . Kentucky demands special attention. The implementation of mitigation strategies for this highly resistant clone seems to be urgently required.

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Beutlich, J. / Guerra, B. / Schroeter, A. / et al: Highly ciprofloxacin resistant Salmonella enterica serovar Kentucky isolates of human and animal origin in Germany. 2013.

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