First report of the multi-resistance gene cfr in Streptococcus suis

The multiresistance gene cfr was identified for the first time in streptococci, namely in the porcine Streptococcus suis isolate S10. The cfr gene was detected on the ∼100 kb plasmid pStrcfr, where it was bracketed by two copies of the novel insertion sequence ISEnfa5, located in the same orientation. The detection of a cfr- and ISEnfa5-containing amplicon by inverse PCR suggests that ISEnfa5 may play a role in the dissemination of cfr.