The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs

Dänicke, Sven GND; Brosig, Bianca GND; Kahlert, S.; Panther, P.; Reinhardt, N.; Diesing, A.-K.; Klüß, Jeannette GND; Kersten, Susanne GND; Valenta, Hana GND; Rothkötter, H.-J.

The plasma elimination kinetics of the Fusarium toxin deoxynivalenol (DON) was investigated in male castrated pigs (40.4 ± 3.7 kg) when infused intravenously either alone (100 µg/kg/h, n = 6) or together with lipopolysaccharides (LPS, 7.5 µg/kg/h, n = 6). The maximum DON concentration after one hour of infusion was significantly higher by 61% in the DON + LPS Group compared to pigs infused with DON alone. The area under the plasma DON concentration vs. time curve of the DON + LPS-group was approximately twice as high as that of the DON-group after 24 h while the initial (0.63 vs. 0.6 h) and terminal half-lifes (2.97 vs. 2.30 h) remained uninfluenced. The apparent volume of distribution and the plasma clearance were significantly lower for the DON + LPS Group compared to the DON group (2.14 vs. 1.45 L/kg and 11.9 vs. 5.87 mL/kg/min). Glucuronidated DON seemed to persist longer in the DON + LPS Group. In conclusion, clearance of DON was decreased during an LPS induced acute phase reaction in pigs. Whether the higher plasma DON concentrations in endotoxemic pigs are due to a hemodynamically associated longer persistence of the DON glucuronide or because of an altered glucuronidation activity needs to be examined further.

Files

Cite

Citation style:

Dänicke, Sven / Brosig, Bianca / Kahlert, S. / et al: The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs. 2012.

Rights

Use and reproduction:
All rights reserved

Export