In Vitro Replication of Varicella-Zoster Virus in Human Retinal Pigment Epithelial Cells

Schmidt-Chanasit, J.; Bleymehl, K.; Rabenau, H.F.; Ulrich, Rainer G. GND; Cinatl, J.; Doerr, H.W.

Here we describe for the first time the productive in vitro infection of human retinal pigment epithelial cells by varicella-zoster virus (VZV), resulting in a typical cytopathic effect (CPE) that is characterized by enlarged cells with increased granularity. Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered

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Schmidt-Chanasit, J. / Bleymehl, K. / Rabenau, H.F. / et al: In Vitro Replication of Varicella-Zoster Virus in Human Retinal Pigment Epithelial Cells. 2008.

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