In Vitro Replication of Varicella-Zoster Virus in Human Retinal
Pigment Epithelial Cells

Schmidt-Chanasit, J.; Bleymehl, K.; Rabenau, H.F.; Ulrich, Rainer G.; Cinatl, J.; Doerr, H.W.

doi:10.1128/JCM.00122-08

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In Vitro Replication of Varicella-Zoster Virus in Human Retinal Pigment Epithelial Cells

Schmidt-Chanasit, J.; Bleymehl, K.; Rabenau, H.F.; Ulrich, Rainer G.; Cinatl, J.; Doerr, H.W.

Here we describe for the first time the productive in vitro infection of human retinal pigment epithelial cells by varicella-zoster virus (VZV), resulting in a typical cytopathic effect (CPE) that is characterized by enlarged cells with increased granularity. Depending on the CPE dissemination, high titers of up to 1.6 x 10(6) PFU of cell-free and cryostable VZV/ml can be recovered

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Erschienen in:: Journal of clinical microbiology
Vol. 46, H. 6 (2008), S. 2122-2124
Band:: 46
Heft:: 6
Datum der Veröffentlichung:: 08.04.2008
DOI:: 10.1128/JCM.00122-08
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: CELLS; EPITHELIAL-CELLS; GERMANY; IN-VITRO; INFECTION; REPLICATION; STRAINS; VIRUS
DDC-Sachgruppe der DNB:: 570 Biowissenschaften, Biologie
Link URL:: http://jcm.asm.org/content/46/6/2122.long
Link URL:: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446866/
Einrichtung:: Friedrich-Loeffler-Institut, Institut für neue und neuartige Tierseuchenerreger
Physischer Standort:: SD/2008/147