Role of Hypercytokinemia in NF-kappa B p50-Deficient Mice after H5N1 Influenza A Virus Infection

Droebner, Karoline GND; Reiling, Sarah J. GND; Planz, Oliver GND

During H5N1 influenza virus infection, proinflammatory cytokines are markedly elevated in the lungs of infected hosts. The significance of this dysregulated cytokine response in H5N1-mediated pathogenesis remains to be determined. To investigate the influence of hypercytokinemia, or "cytokine storm," a transgenic mouse technology was used. The classical NF-kappa B pathway regulates the induction of most proinflammatory cytokines. Deletion of the p50 subunit leads to a markedly reduced expression of the NF-kappa B-regulated cytokines and chemokines. Here we show that H5N1 influenza virus infection of this transgenic mouse model resulted in a lack of hypercytokinemia but not in altered pathogenesis

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Droebner, Karoline / Reiling, Sarah J. / Planz, Oliver: Role of Hypercytokinemia in NF-kappa B p50-Deficient Mice after H5N1 Influenza A Virus Infection. 2008.

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