High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

Brehm, Katharina Erika Gerda; Kumar, Naveen; Thulke, H.H.; Haas, Bernd

doi:10.1016/j.vaccine.2008.01.038

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Veröffentlicht

High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

Brehm, Katharina Erika Gerda ; Kumar, Naveen ; Thulke, H.H.; Haas, Bernd

In a series of three homologous and eight heterologous challenge experiments, it was shown that high potency vaccines against foot-and-mouth disease (FMD) serotype A can induce protection even against heterologous challenge infection with viruses that give low r-values with the vaccine strains. The challenge virus specific neutralizing antibody response on the day of challenge (21 days post vaccination) generally correlated with protection. (C) 2008 Elsevier Ltd. All rights reserved

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Erschienen in:: Vaccine
Vol. 26, H. 13 (2008), S. 1681-1687
Band:: 26
Heft:: 13
Datum der Veröffentlichung:: 12.02.2008
DOI:: 10.1016/j.vaccine.2008.01.038
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: antibody; CATTLE; CHALLENGE; DISEASE; ELISA; foot-and-mouth disease virus; GERMANY; IMMUNITY; INDUCE; INFECTION; PROTECTION; protection by vaccines; serology; STRAINS; VIRUS
DDC-Sachgruppe der DNB:: 630 Landwirtschaft, Veterinärmedizin
Link URL:: http://www.sciencedirect.com/science/article/pii/S0264410X08000741
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Virusdiagnostik
Physischer Standort:: SD/2008/23