Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L)

Kadlec, Kristina; Schwarz, Stefan

doi:10.1128/AAC.01128-08

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Identification of a Novel Trimethoprim Resistance Gene, dfrK, in a Methicillin-Resistant Staphylococcus aureus ST398 Strain and Its Physical Linkage to the Tetracycline Resistance Gene tet(L)

A novel trimethoprim resistance gene, designated dfrK, was detected in close proximity to the tetracycline resistance gene tet(L) on the ca. 40-kb plasmid pKKS2187 in a porcine methicillin (meticillin)-resistant Staphylococcus aureus isolate of sequence type 398. The dfrK gene encodes a 163-amino-acid dihydrofolate reductase that differs from all so-far-known dihydrofolate reductases

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Erschienen in:: Antimicrobial agents and chemotherapy
Vol. 53, H. 2 (2009), S. 776-778
Band:: 53
Heft:: 2
Datum der Veröffentlichung:: 17.11.2008
DOI:: 10.1128/AAC.01128-08
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: CLONING; DIHYDROFOLATE-REDUCTASE; EMERGENCE; EVOLUTION; GENE; GERMANY; HUMANS; IDENTIFICATION; IS257; MONITORING PROGRAM 2004-2006; PLASMIDS; SEQUENCE; STRAIN; VIRULENCE
DDC-Sachgruppe der DNB:: 610 Medizin, Gesundheit, Ernährung
Link URL:: http://aac.asm.org/content/53/2/776.long
Link URL:: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630608/
Einrichtung:: Friedrich-Loeffler-Institut, Institut für Nutztiergenetik
Physischer Standort:: SD/2009/26