Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil Using Functional Metagenomics

Lang, K.S.; Anderson, J.M.; Schwarz, Stefan GND; Williamson, L.; Handelsman, J.; Singer, R.S.

Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily

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Lang, K.S. / Anderson, J.M. / Schwarz, Stefan / et al: Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil Using Functional Metagenomics. 2010.

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