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Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil Using Functional Metagenomics

Lang, K.S.; Anderson, J.M.; Schwarz, Stefan GND; Williamson, L.; Handelsman, J.; Singer, R.S.

Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily

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Published in:
Applied and environmental microbiology
Vol. 76, H. 15 (2010), p. 5321-5326
Date Issued:
11.06.2010
DOI:
10.1128/AEM.00323-10
Language:
English
Type of Resource:
Text
Keywords:
animal; DNA; GENE; GENES; GERMANY; PROTEIN; RESISTANCE; susceptibility; veterinary
DDC subject of DNB:
570 Life science
URL:
Volltext (ASM)
URL:
Volltext (PMC)
Institution:
Friedrich-Loeffler-Institut, Institute of Farm Animal Genetics
Physical Location:
SD/2010/208

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Citation style:

Lang, K.S. / Anderson, J.M. / Schwarz, Stefan / et al: Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil Using Functional Metagenomics. 2010.

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