Emergence and dissemination of ESBL and fluoroquinolone resistance in Enterobacteriaceae - the RESET Network : Vortrag auf der 63. Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM)

Background and Objective: Enterobacteriaceae have been shown to play a crucial role in the transmission of antimicrobial resistances. The most prominent enterobacterial species in humans and animals are Escherichia (E.) coli and Salmonella (S.) enterica. Dissemination of antibiotic resistance can be due to the transfer of resistant bacteria between different host organisms or by horizontal transfer of resistance properties between isolates of the same or different species and genera within and beyond the family Enterobacteriaceae. Especially, resistance to beta-lactams mediated by production of Extended-spectrum beta-lactamases (ESBL) and resistance to (fluoro)quinolones influenced by different plasmid-mediated quinolone resistance determinants are of concern since they limit dramatically the therapeutic options in both, veterinary and human medicine. Therefore the RESET research consortium aims at assessing the impact of different origins, transmission routes and pathogen attributes on the risk for humans being exposed to ESBL-producing and (fluoro)quinolone-resistant Enterobacteriaceae. Studies and Methods: The RESET consortium consists of 10 network partners and 5 associated partners from human and veterinary medicine, fundamental and application-oriented research and epidemiology. The RESET network will perform different studies to provide indispensable, reliable information on - the pathogen distribution in specific human and animal populations as well as in food, feed and the environment, - the occurrence of ESBL and PMQR (plasmid-mediated quinolone resistance) genes within the pathogen populations, - the transmission pathways between the different populations (animal-, environment-, human- or pathogen-related), and - the impact of the use of antibiotics in animals and humans in respect to the resistance situation. Conclusion: In 2008, the Federal Ministry of Health (BMG) started the DART (Deutsche Antibiotika-Resistenzstrategie) initiative for prevention and control of further spread of antimicrobial resistances in human and veterinary medicine. The RESET network includes different interacting and complementary studies on factors associated with the dissemination of emerging resistance properties in Enterobacteriaceae from humans, animals and the environment. As such, the results expected from RESET will be a substantial contribution to DART.