Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN)

Mantion, A.; Graf, P.; Florea, I.; Haase, A.; Thünemann, A. F.; Masic, A.; Ersen, O.; Rabu, P.; Meier, W.; Luch, A.; Taubert, A.

Peptide-modified silver nanoparticles have been coated with an erbium-doped silica layer using a method inspired by silica biomineralization. Electron microscopy and small-angle X-ray scattering confirm the presence of an Ag/peptide core and silica shell. The erbium is present as small Er(2)O(3) particles in and on the silica shell. Raman, IR, UV-Vis, and circular dichroism spectroscopies show that the peptide is still present after shell formation and the nanoparticles conserve a chiral plasmon resonance. Magnetic measurements find a paramagnetic behavior. In vitro tests using a macrophage cell line model show that the resulting multicomponent nanoparticles have a low toxicity for macrophages, even on partial dissolution of the silica shell.

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Mantion, A. / Graf, P. / Florea, I. / et al: Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN). 2011.

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