Poultry associated Salmonella enterica subsp. enterica serovar 4,12:d:- reveals high clonality and a distinct pathogenicity gene repertoire

Huehn, S.; Bunge, C.; Junker, E.; Helmuth, R.; Malorny, B.

A European baseline survey during the years 2005 and 2006 has revealed that the monophasic Salmonella enterica subsp. enterica serovar 4,12:d:- was with 23.6% the most frequently isolated serovar in German broiler flocks. In Denmark and the United Kingdom its serovar prevalence was 15.15% and 2.8%, respectively. Although poultry is a major source of human salmonellosis S. 4,12:d:- is rarely isolated in humans (approx. 0.09% per year). Molecular typing studies using pulsed-field gel electrophoresis and DNA microarray analysis show that the serovar is highly clonal and lacks genes with known contributions to pathogenicity. In contrast to other poultry associated serovars, all strains were susceptible to 17 antimicrobial agents tested and did not encode any resistance determinant. Furthermore S. 4,12:d:- lacked genes involved in the galactonate metabolism and the glycolysis and glyconeogenesis important for the energy production of the cells. The conclusion of the study is that S. 4,12:d:- seems to be primarily adapted to broilers and therefore cause only rarely infections in humans

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Huehn, S. / Bunge, C. / Junker, E. / et al: Poultry associated Salmonella enterica subsp. enterica serovar 4,12:d:- reveals high clonality and a distinct pathogenicity gene repertoire. 2009.

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