Phage therapy: Facts and fiction

Skurnik, M.; Strauch, E.

doi:10.1016/j.ijmm.2005.09.002

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Phage therapy: Facts and fiction

Recent examples of the use of bacteriophages in controlling bacterial infections are presented, some of which show therapeutic promise. The therapeutic use of bacteriophages, possibly in combination with antibiotics, may be a valuable approach. However, it is also quite clear that the safe and controlled use of phage therapy will require detailed information on the properties and behavior of specific phage-bacterium systems, both in vitro and especially in vivo. In vivo susceptibility of bacterial pathogens to bacteriophages is still largely poorly understood and future research on more phage-bacterium systems has to be undertaken to define the requirements for successful phage treatments. (C) 2005 Elsevier GmbH. All rights reserved

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Erschienen in:: International Journal of Medical Microbiology
Vol. 296, H. 1 (2006), S. 5-14
Band:: 296
Heft:: 1
Datum der Veröffentlichung:: 2006
DOI:: 10.1016/j.ijmm.2005.09.002
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: antibiotic; approach; assessment; Bacterial Infections; BACTERIOPHAGE LYTIC ENZYME; Behavior; Berlin; BROILER-CHICKENS; COLI RESPIRATORY-INFECTION; ENTEROCOLITICA SEROTYPE O-3; Escherichia coli; ESCHERICHIA-COLI; Germany; In Vitro; in vivo; IN-VITRO; IN-VIVO; INFECTION; INFECTIONS; INFORMATION; LIPOPOLYSACCHARIDE OUTER CORE; PATHOGENS; phage therapy; PSEUDOMONAS-PLECOGLOSSICIDA; reference; Research; review; Risk; Risk Assessment; RISK-ASSESSMENT; STREPTOCOCCUS-PNEUMONIAE; SUSCEPTIBILITY; SYSTEM; SYSTEMS; therapeutic use; THERAPY; TIME; TIMES; treatment; VIBRIO-CHOLERAE; VITRO; VIVO; Yersinia enterocolitica; YERSINIA-ENTEROCOLITICA
DDC-Sachgruppe der DNB:: 600 Technik
Link URL:: http://www.sciencedirect.com/science/article/pii/S1438422105001293
Einrichtung:: Bundesinstitut für Risikobewertung, Bundesinstitut für Risikobewertung (bis Juni 2014), Abteilung 4 - Biologische Sicherheit (bis Juni 2014)