Toxikogenetik und Toxikogenomik. Bedeutung und Anwendung in der Arbeitsmedizin

Schulz, T.

doi:10.1007/s00103-006-0046-0

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Toxikogenetik und Toxikogenomik. Bedeutung und Anwendung in der Arbeitsmedizin

Xenobiotic metabolising enzymes modify most organic compounds into water soluble compounds. Sequence variations of these enzymes can lead to significant interindividual differences in the metabolism of xenobiotics. This review covers important sequence variations of phase I (cytochrome P450) and phase II (glutathion S-transferases, N-acetyltransferases, sulfotransferases, UDP-glucuronosyl transferases) enzymes and elucidates the significance for occupational health. At the present time, the determination of various sequence variations is not suitable for an individual risk assessment in occupational health

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Erschienen in:: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Vol. 49, H. 10 (2006), S. 1004-1010
Band:: 49
Heft:: 10
Datum der Veröffentlichung:: 2006
DOI:: 10.1007/s00103-006-0046-0
Sprache:: Deutsch
Ressourcentyp:: Text
Schlagwörter:: Acetyltransferases; article; assessment; Berlin; comparative; Comparative Study; compounds; Cytochrome P-450 Enzyme System; Cytochrome p450; DEHYDROGENASE; Determination; DIFFERENCE; English Abstract; ENZYME; ENZYMES; enzymology; genetics; Glucosephosphate Dehydrogenase; Glutathione Transferase; HEALTH; Humans; lead; liver; metabolism; Occupational Health; PHASE; Polymorphism,Genetic; review; Risikobewertung; Risk; Risk Assessment; RISK-ASSESSMENT; SEQUENCE; study; Sulfotransferases; SYSTEM; TIME; toxicity; Toxicogenetics; Transferases; variation; WATER; Xenobiotics
DDC-Sachgruppe der DNB:: 600 Technik
Link URL:: http://www.springerlink.com/content/01174312618x47rr/
Einrichtung:: Bundesinstitut für Risikobewertung, Bundesinstitut für Risikobewertung (bis Juni 2014), Abteilung 7 - Produktsicherheit (bis Juni 2014)