Detection and identification of phenazone-type drugs and their microbial metabolites in ground and drinking water applying solid-phase extraction and gas chromatography with mass spectrometric detection

Zühlke, S.; Dunnbier, U.; Heberer, T.

doi:10.1016/j.chroma.2004.08.051

referiert

Veröffentlicht

Detection and identification of phenazone-type drugs and their microbial metabolites in ground and drinking water applying solid-phase extraction and gas chromatography with mass spectrometric detection

A new analytical method applying in situ derivatization was developed to enable the extraction of polar drug metabolites from water samples by solid-phase extraction (SPE). An additional derivatization by silylation was used to enhance the sensitivity of analyte detection by gas chromatography-mass spectrometry (GC-MS). Thus, the two metabolites 1,5-di-methyl-1,2-dehydro-3-pyrazolone (DP) and 4-(2-methylethyl)-1,5-dimethyl-1,2-dehydro-3-pyrazolone (PDP), postulated for the degradation of phenazone and propyphenazone, were identified and detected up to the microg/L level in raw and drinking water samples from public water supply

Dateien

beschränkter Zugriff

Einordnung

Erschienen in:: Journal of chromatography / A
Vol. 1050, H. 2 (2004), S. 201-209
Band:: 1050
Heft:: 2
Datum der Veröffentlichung:: 2004
DOI:: 10.1016/j.chroma.2004.08.051
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: article; Berlin; chemistry; CHROMATOGRAPHY; CHROMATOGRAPHY-MASS SPECTROMETRY; degradation; DERIVATIZATION; detection; Drinking; drinking water; DRINKING-WATER; DRUG; DRUG METABOLITES; drugs; EXTRACTION; Food; Gas Chromatography-Mass Spectrometry; GAS-CHROMATOGRAPHY; GC-MS; Germany; IDENTIFICATION; LEVEL; metabolite; METABOLITES; method; propyphenazone; Public; RAW; SAMPLES; SENSITIVITY; SOLID-PHASE EXTRACTION; SPECTROMETRY; WATER; WATER SAMPLES
DDC-Sachgruppe der DNB:: 600 Technik
Link URL:: http://www.sciencedirect.com/science/article/pii/S0021967304014013
Einrichtung:: Bundesinstitut für Risikobewertung, Bundesinstitut für Risikobewertung (bis Juni 2014), Abteilung 6 - Chemikaliensicherheit (bis Juni 2014)