Formation of an artifact of diclofenac during acidic extraction of environmental water samples

Reddersen, K.; Heberer, T.

doi:10.1016/S0021-9673(03)01173-7

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Formation of an artifact of diclofenac during acidic extraction of environmental water samples

Solid-phase extraction at an acidic pH is used as a common sample preparation method for analyzing residues of the analgesic drug diclofenac (2-[(2,6-dichlorophenyl)amino] benzeneacetic acid) in environmental water samples. This paper describes the matrix-dependent formation of an artifact of diclofenac during sample preparation resulting in an up to 40% underestimation of diclofenac concentrations especially in matrix-prone samples such as sewage effluents or surface water. The artifact most likely being formed during acidification of the sample was unequivocally identified as 1-(2,6-dichlorophenyl)indolin-2-one by capillary gas chromatography-mass spectrometry. To avoid an underestimation of the analytical results quantification of both diclofenac and its artifact is recommended

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Erschienen in:: Journal of chromatography / A
Vol. 1011, H. 1-2 (2003), S. 221-226
Band:: 1011
Heft:: 1-2
Datum der Veröffentlichung:: 2003
DOI:: 10.1016/S0021-9673(03)01173-7
Sprache:: Englisch
Ressourcentyp:: Text
Schlagwörter:: ACID; AGENT; AGENTS; analysis; Anti-Inflammatory Agents,Non-Steroidal; article; Berlin; chemical; chemistry; CHROMATOGRAPHY-MASS SPECTROMETRY; concentration; diclofenac; DRUG; EFFLUENTS; EXTRACTION; Food; Gas Chromatography-Mass Spectrometry; Germany; Mass Fragmentography; method; pollutants; QUANTIFICATION; residue; RESIDUES; SAMPLES; SEWAGE; sewage effluents; SOLID-PHASE EXTRACTION; SPECTROMETRY; SURFACE; surface water; SURFACE-WATER; WATER; Water Pollutants,Chemical; WATER SAMPLES
DDC-Sachgruppe der DNB:: 600 Technik
Link URL:: http://dx.doi.org/10.1016/S0021-9673(03)01173-7
Einrichtung:: Bundesinstitut für Risikobewertung, Bundesinstitut für Risikobewertung (bis Juni 2014), Abteilung 6 - Chemikaliensicherheit (bis Juni 2014)